Annika Sääf
Post-Doctoral Fellow
1. Genome-wide analysis of epithelial cell polarization
It is well known that intestinal epithelial cells form two distinct domains
(the apical and basal-lateral membranes), which are separated by tight junctions,
and that they form a well-differentiated brush-border on the apical surface.
Less is known about the gene-expression pattern behind this complex cell architecture.
By using DNA microarrays, we are studying epithelial cell differentiation and
polarization on a genomic scale. This project is in collaboration with Jennifer
Halbleib and James Nelson, Dept of Molecular and Cellular Physiology, Stanford University.
2. Gene-expression pattern in human fat
In this project, I am using DNA microarrays to analyze adipose tissue from different
sites of the human body. We want to find out what differences there are in the gene
expression patterns depending on the adipose tissue topographic position, what
differences there are between metabolic and mechanical fat, as well as differences
in gene expression patterns between fat from obese and normal people.
Contact info